补体因子B基因多态性与年龄相关性黄斑变性的风险：一项荟萃分析。
Complement factor B gene polymorphisms and risk of age-related macular degeneration: A meta-analysis.
作者信息
Su Yun, Hu Zizhong, Pan Ting, Chen Lu, Xie Ping, Liu Qinghuai
机构信息
Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.
Department of Ophthalmology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, P.R. China.
出版信息
Eur J Ophthalmol. 2020 Jul;30(4):743-755. doi: 10.1177/1120672119840245. Epub 2019 Apr 12.
OBJECTIVE
To investigate the potential correlation between complement factor B polymorphisms and age-related macular degeneration.
METHODS
We retrieved relevant articles systematically by searching PubMed and Web of Science databases. The pooled odds ratios and 95% confidence intervals were calculated for five complement factor B polymorphism rs641153, rs4151667, rs1048709, rs2072633, and rs12614 using data from included articles in both random effects and fixed effect models. Subgroup meta-analysis based on age-related macular degeneration type, choroidal neovascular disease (rs641153 and rs4151667), geographic atrophy (rs641153 and rs4151667), and races was also performed.
RESULTS
In the overall comparison, we observed that the distribution of rs641153 and the risk of age-related macular degeneration were significantly correlated (p < 0.00001). Similar results were obtained in subgroup analysis based on race (Caucasians, p < 0.00001; Asians, p = 0.003) and age-related macular degeneration type (choroidal neovascular disease, p < 0.00001; geographic atrophy, p = 0.04). As for complement factor B rs4151667, the genotypic effects were also demonstrated statistically significant in overall analysis (p < 0.00001) and only in Caucasians diagnosed with choroidal neovascular disease (p = 0.004), but not in Asians. Moreover, no statistically significant correlations between the complement factor B polymorphisms rs1048709 (p = 0.63), rs2072633 (p = 0.72), rs12614 (p = 0.98) and susceptibility to age-related macular degeneration were detected in either overall or subgroup analysis.
CONCLUSION
Collectively, we demonstrated that the complement factor B genes rs641153 and rs4151667, but not rs1048709, rs2072633, rs12614, were associated with the susceptibility of age-related macular degeneration and might play predictive roles in future age-related macular degeneration diagnosis. More studies are needed to verify these findings.
目的
探讨补体因子B基因多态性与年龄相关性黄斑变性之间的潜在关联。
方法
通过检索PubMed和Web of Science数据库系统地获取相关文章。使用纳入文章的数据，在随机效应模型和固定效应模型中计算5个补体因子B基因多态性rs641153、rs4151667、rs1048709、rs2072633和rs12614的合并比值比及95%置信区间。还基于年龄相关性黄斑变性类型、脉络膜新生血管疾病（rs641153和rs4151667）、地图样萎缩（rs641153和rs4151667）以及种族进行亚组荟萃分析。
结果
在总体比较中，我们观察到rs641153的分布与年龄相关性黄斑变性的风险显著相关（p < 0.00001）。在基于种族（白种人，p < 0.00001；亚洲人，p = 0.003）和年龄相关性黄斑变性类型（脉络膜新生血管疾病，p < 0.00001；地图样萎缩，p = 0.04）的亚组分析中也获得了类似结果。至于补体因子B rs4151667，其基因型效应在总体分析中也显示出统计学显著性（p < 0.00001），且仅在诊断为脉络膜新生血管疾病的白种人中具有统计学显著性（p = 0.004），而在亚洲人中无显著性。此外，在总体分析或亚组分析中均未检测到补体因子B基因多态性rs1048709（p = 0.63）、rs2072633（p = 0.72）、rs12614（p = 0.98）与年龄相关性黄斑变性易感性之间存在统计学显著相关性。
结论
总体而言，我们证明补体因子B基因rs641153和rs4151667，而非rs1048709、rs2072633、rs12614，与年龄相关性黄斑变性的易感性相关，可能在未来年龄相关性黄斑变性诊断中发挥预测作用。需要更多研究来验证这些发现。
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