从黑老虎根中分离得到的四个具有6/6/5/6稠环体系的14(13 → 12)-乌苏烷型三萜类化合物。
Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea.
作者信息
Xu Hou-Chao, Hu Kun, Sun Han-Dong, Puno Pema-Tenzin
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
出版信息
Nat Prod Bioprospect. 2019 Jun;9(3):165-173. doi: 10.1007/s13659-019-0203-4. Epub 2019 Apr 11.
Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A-D (1-4), were isolated from the roots of Kadsura coccinea, and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of 1 was ambiguously verified by single-crystal X-ray diffraction, while the structure of 2, which features a novel 8,16-epoxy motif, was validated by quantum chemical calculation of NMR parameters and ECD spectrum. Moreover, 1 and 4 were found to exhibited anticoagulant activity, while 3 and 4 were found to possess anti-platelet aggregation activity.
从黑老虎根部分离得到了4个新的重排6/6/5/6-稠合羊毛甾烷型三萜类化合物，即黑老虎萜A-D（1-4），其结构主要通过对光谱数据的综合分析得以阐明。此外，1的结构通过单晶X射线衍射得到了明确验证，而具有新颖8,16-环氧基序的2的结构则通过核磁共振参数和电子圆二色光谱的量子化学计算得到了确认。此外，发现1和4具有抗凝活性，而3和4具有抗血小板聚集活性。
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