基于颈动脉影像学表型对心血管风险计算器的影响：AECRS1.0。
Effect of carotid image-based phenotypes on cardiovascular risk calculator: AECRS1.0.
机构信息
Department of Cardiology, Indraprastha Apollo Hospitals, New Delhi, India.
Department of ECE, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra, India.
出版信息
Med Biol Eng Comput. 2019 Jul;57(7):1553-1566. doi: 10.1007/s11517-019-01975-2. Epub 2019 Apr 15.
Today, the 10-year cardiovascular risk largely relies on conventional cardiovascular risk factors (CCVRFs) and suffers from the effect of atherosclerotic wall changes. In this study, we present a novel risk calculator AtheroEdge Composite Risk Score (AECRS1.0), designed by fusing CCVRF with ultrasound image-based phenotypes. Ten-year risk was computed using the Framingham Risk Score (FRS), United Kingdom Prospective Diabetes Study 56 (UKPDS56), UKPDS60, Reynolds Risk Score (RRS), and pooled composite risk (PCR) score. AECRS1.0 was computed by measuring the 10-year five carotid phenotypes such as IMT (ave., max., min.), IMT variability, and total plaque area (TPA) by fusing eight CCVRFs and then compositing them. AECRS1.0 was then benchmarked against the five conventional cardiovascular risk calculators by computing the receiver operating characteristics (ROC) and area under curve (AUC) values with a 95% CI. Two hundred four IRB-approved Japanese patients' left/right common carotid arteries (407 ultrasound scans) were collected with a mean age of 69 ± 11 years. The calculators gave the following AUC: FRS, 0.615; UKPDS56, 0.576; UKPDS60, 0.580; RRS, 0.590; PCRS, 0.613; and AECRS1.0, 0.990. When fusing CCVRF, TPA reported the highest AUC of 0.81. The patients were risk-stratified into low, moderate, and high risk using the standardized thresholds. The AECRS1.0 demonstrated the best performance on a Japanese diabetes cohort when compared with five conventional calculators. Graphical abstract AECRS1.0: Carotid ultrasound image phenotype-based 10-year cardiovascular risk calculator. The figure provides brief overview of the proposed carotid image phenotype-based 10-year cardiovascular risk calculator called AECRS1.0. AECRS1.0 was also benchmarked against five conventional cardiovascular risk calculators (Framingham Risk Score (FRS), United Kingdom Prospective Diabetes Study 56 (UKPDS56), UKPDS60, Reynolds Risk Score (RRS), and pooled composite risk (PCR) score).
今天，10 年心血管风险在很大程度上依赖于传统心血管风险因素（CCVRFs），并受到动脉粥样硬化壁变化的影响。在这项研究中，我们提出了一种新的风险计算器 AtheroEdge 综合风险评分（AECRS1.0），它通过融合 CCVRF 与基于超声图像的表型来设计。使用 Framingham 风险评分（FRS）、英国前瞻性糖尿病研究 56（UKPDS56）、UKPDS60、Reynolds 风险评分（RRS）和综合复合风险（PCR）评分计算 10 年风险。AECRS1.0 通过测量 10 年五个颈动脉表型（如 IMT（平均、最大、最小）、IMT 变异性和总斑块面积（TPA））来计算，方法是融合 8 个 CCVRF 然后将它们组合在一起。然后通过计算接收者操作特征（ROC）和曲线下面积（AUC）值，并使用 95%CI 对五个传统心血管风险计算器进行基准测试。收集了 204 名经过 IRB 批准的日本患者的左右颈总动脉（407 次超声扫描），平均年龄为 69±11 岁。计算器给出了以下 AUC：FRS，0.615；UKPDS56，0.576；UKPDS60，0.580；RRS，0.590；PCR，0.613；AECRS1.0，0.990。当融合 CCVRF 时，TPA 报告的 AUC 最高为 0.81。使用标准化阈值将患者分为低、中、高风险组。与五个传统计算器相比，AECRS1.0 在日本糖尿病队列中表现出最佳性能。
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