Transcription Factors and Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration.

Cortical interneurons are derived from the subpallium and reach the developing cortex through long tangential migration. Mature cortical interneurons are characterized by remarkable morphological, molecular, and functional diversity. The calcium-binding protein parvalbumin (PV) and neuropeptide somatostatin (SST) identify most medial ganglionic eminence (MGE)-derived cortical interneurons. Previously, we demonstrated that plays a curial transcriptional role in regulating MGE-derived cortical interneuron development. Here, we show that SP8 protein is weekly expressed in the MGE mantle zone of wild type mice but upregulated in null mutants. PV cortical interneurons were severely lost in double conditional knockouts due to defects in tangential migration compared with single mutants, suggesting that coordinately regulate PV cortical interneuron development. We provide evidence that activity is required for normal MGE-derived cortical interneuron migration, at least in part, through regulating the expression of , , and .