银离子在不同盐浓度下调节含有胞嘧啶、甲基胞嘧啶和羟甲基胞嘧啶的DNA双链体的稳定性。
Silver(I) ions modulate the stability of DNA duplexes containing cytosine, methylcytosine and hydroxymethylcytosine at different salt concentrations.
作者信息
Wang Yong, Ritzo Brandon, Gu Li-Qun
机构信息
Department of Biological Engineering, University of Missouri, 134 research park, Columbia, MO 65211, USA.
出版信息
RSC Adv. 2015;5(4):2655-2658. doi: 10.1039/c4ra14490b. Epub 2014 Dec 4.
Abstract
Silver(I) ions can stabilize cytosine-cytosine, cytosine (C)-methylcytosine (5mC) and cytosine-hydroxymethylcytosine (5hmC) mismatched-base pairs. While cytosine modifications regulate DNA stability to regulate cellular functions, silver ions can modulate the stability of C-C, C-5mC and C-5hmC containing DNA duplexes in a salt concentration dependent manner.
摘要
银离子可稳定胞嘧啶-胞嘧啶、胞嘧啶（C）-甲基胞嘧啶（5mC）和胞嘧啶-羟甲基胞嘧啶（5hmC）错配碱基对。虽然胞嘧啶修饰通过调节DNA稳定性来调控细胞功能，但银离子能够以盐浓度依赖的方式调节含C-C、C-5mC和C-5hmC的DNA双链体的稳定性。
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