Division of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, 12801 18 E. 17th Ave, MS 8117, Aurora, CO, 80045, USA.
Hematology/Oncology Section, Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO, USA.
Curr Treat Options Oncol. 2019 Apr 22;20(5):43. doi: 10.1007/s11864-019-0650-5.
The epidemiology of head and neck squamous cell carcinoma (HNSCC) has shifted dramatically over the last 50 years, as smoking-related HNSCCs decrease in incidence while human papillomavirus (HPV)-related cancers rise. The shift in HNSCC risk factors has changed patient demographics, the distribution of affected anatomical subsites, and prognosis of this illness. As such, the medical community has responded by devising novel staging systems and prevention strategies. The medical community will require continued vigilance in reducing HNSCC traditional risks factors for HNSCC, such as cigarette use, and emerging risk like HPV infection.
头颈部鳞状细胞癌（HNSCC）的流行病学在过去 50 年中发生了巨大变化，随着与吸烟相关的 HNSCC 发病率下降，而与人类乳头瘤病毒（HPV）相关的癌症发病率上升。HNSCC 危险因素的变化改变了患者的人口统计学特征、受影响的解剖部位分布以及该疾病的预后。因此，医学界通过设计新的分期系统和预防策略做出了回应。医学界将需要继续警惕降低 HNSCC 的传统危险因素，如吸烟，并警惕 HPV 感染等新的危险因素。
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