Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA.
Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
Int J Mol Sci. 2019 Apr 12;20(8):1811. doi: 10.3390/ijms20081811.
The skin is a complex organ that has devised numerous strategies, such as physical, chemical, and microbiological barriers, to protect the host from external insults. In addition, the skin contains an intricate network of immune cells resident to the tissue, crucial for host defense as well as tissue homeostasis. In the event of an insult, the skin-resident immune cells are crucial not only for prevention of infection but also for tissue reconstruction. Deregulation of immune responses often leads to impaired healing and poor tissue restoration and function. In this review, we will discuss the defensive components of the skin and focus on the function of skin-resident immune cells in homeostasis and their role in wound healing.
皮肤是一种复杂的器官，它设计了许多策略，如物理、化学和微生物屏障，以保护宿主免受外界伤害。此外，皮肤中还存在着一个复杂的免疫细胞网络，这些细胞驻留在组织中，对于宿主防御和组织稳态都至关重要。在受到伤害时，皮肤驻留的免疫细胞不仅对于预防感染至关重要，对于组织重建也是如此。免疫反应的失调常常导致愈合受损和组织恢复不良及功能受损。在这篇综述中，我们将讨论皮肤的防御成分，并重点讨论皮肤驻留免疫细胞在稳态中的功能及其在伤口愈合中的作用。
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