EAST1 毒素：一种与人类和动物散发性腹泻有关的神秘分子。
EAST1 toxin: An enigmatic molecule associated with sporadic episodes of diarrhea in humans and animals.
机构信息
Faculté de médecine vétérinaire, Université de Montréal, Montréal, Québec, J2S 2M2, Canada.
出版信息
J Microbiol. 2019 Jul;57(7):541-549. doi: 10.1007/s12275-019-8651-4. Epub 2019 Jun 27.
EAST1 is produced by a subset of enteroaggregative Escherichia coli strains. This toxin is a 38-amino acid peptide of 4100 Da. It shares 50% homology with the enterotoxic domain of STa and interacts with the same receptor. The mechanism of action of EAST1is proposed to be identical to that of STa eliciting a cGMP increase. EAST1 is associated with diarrheal disease in Man and various animal species including cattle and swine. Nevertheless, as EAST1-positive strains as well as culture supernatants did not provoke unequivocally diarrhea either in animal models or in human volunteers, the role of this toxin in disease is today still debated. This review intent is to examine the role of EAST1 toxin in diarrheal illnesses.
EAST1 由一组肠聚集性大肠杆菌菌株产生。这种毒素是一个 38 个氨基酸的 4100Da 肽。它与 STa 的肠毒性结构域具有 50%的同源性，并与相同的受体相互作用。EAST1 的作用机制被认为与 STa 引起 cGMP 增加相同。EAST1 与人类和包括牛和猪在内的各种动物物种的腹泻病有关。然而，由于 EAST1 阳性菌株以及培养上清液在动物模型或人类志愿者中均未引起明确的腹泻，因此该毒素在疾病中的作用目前仍存在争议。本文旨在探讨 EAST1 毒素在腹泻病中的作用。
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