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肩胛骨软骨肉瘤:一例报告。

Scapula chondrosarcoma: A case report.

作者信息

Qiang Shuai, Ma Xin-Nan, Wang Hong-Wei, Lv Song-Cen

机构信息

Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.

Department of Orthopedics, Second Affiliated Hospital of Harbin Medical University, Harbin City, Heilongjiang Province, China.

出版信息

Medicine (Baltimore). 2019 Apr;98(17):e15388. doi: 10.1097/MD.0000000000015388.

Abstract

RATIONALE

Chondrosarcoma is a malignant mesenchymal tumor originating from cartilage. The pelvis, ribs, femur, and humerus are the most frequently affected sites, and scapula involvement is relatively rare. The aim of the present study was to report a case of chondrosarcoma in the scapula.

PATIENT CONCERNS

A 42-year-old woman presented with a 3-month history of a painful mass in the right scapula.

DIAGNOSES AND INTERVENTION

The patient underwent tumor resection. The post-operative pathological diagnosis was scapula chondrosarcoma.

OUTCOMES

Following resection, the patient continued to receive routine follow-up care. There was no recurrence or tumor metastasis at a follow-up of 5 years.

CONCLUSIONS

Surgery remains the primary therapy for chondrosarcoma. One of the greatest challenges in the management of chondrosarcoma is to accurately assess tumor grade before surgical intervention. Chemotherapy and radiotherapy have been applied without success. Chemo- and radioresistance have been examined beyond classic phenotypic properties to identify more efficient therapeutic strategies. Therefore, development of future novel therapies is contingent upon elucidating the molecular mechanisms of chondrosarcoma.

摘要

理论依据

软骨肉瘤是一种起源于软骨的恶性间充质肿瘤。骨盆、肋骨、股骨和肱骨是最常受累的部位,肩胛骨受累相对少见。本研究的目的是报告一例肩胛骨软骨肉瘤病例。

患者情况

一名42岁女性,右肩胛骨疼痛性肿块3个月。

诊断与干预

患者接受了肿瘤切除术。术后病理诊断为肩胛骨软骨肉瘤。

结果

切除术后,患者继续接受常规随访。随访5年无复发或肿瘤转移。

结论

手术仍然是软骨肉瘤的主要治疗方法。软骨肉瘤治疗中最大的挑战之一是在手术干预前准确评估肿瘤分级。化疗和放疗应用均未成功。除了经典的表型特性外,还对化疗和放疗耐药性进行了研究,以确定更有效的治疗策略。因此,未来新型疗法的开发取决于阐明软骨肉瘤的分子机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e22b/6831252/55c09ac7231d/medi-98-e15388-g001.jpg

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