柴胡皂苷 A 可预防葡聚糖硫酸钠诱导的小鼠结肠炎。
Saikosaponin A protects against dextran sulfate sodium-induced colitis in mice.
机构信息
Department of Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, China.
Department of Pharmacy, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, China.
出版信息
Int Immunopharmacol. 2019 Jul;72:454-458. doi: 10.1016/j.intimp.2019.04.024.
Ulcerative colitis, one of the most important inflammatory bowel diseases, affects millions of people worldwide. The aim of this study was to investigate the effects of Saikosaponin A on dextran sulfate sodium (DSS)-induced colitis in mice. The mice were treated with 2.5% DSS for 5 d to induce acute colitis. Saikosaponin A was given 3 d before and during DSS treatment by intragastric administration. The results showed that Saikosaponin A significantly inhibited DSS-induced body weight loss and shortening of colon length. DSS-induced colonic histological changes and MPO activity were also prevented by treatment of Saikosaponin A. The levels of TNF-α and IL-1ß were increased by DSS and dose-dependently inhibited by Saikosaponin A. Furthermore, Saikosaponin A significantly inhibited DSS-induced NF-κB activation and up-regulated the expression of LXRα. Taken together, our results indicated that Saikosaponin A had protective effects against DSS-induced colitis. Saikosaponin A protected DSS-induced colitis through inhibiting inflammatory response.
溃疡性结肠炎是最重要的炎症性肠病之一，影响着全世界数百万人。本研究旨在探讨柴胡皂苷 A 对葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎的影响。通过灌胃给予小鼠 2.5% DSS 5 天以诱导急性结肠炎。在 DSS 治疗前 3 天和治疗期间给予柴胡皂苷 A。结果表明，柴胡皂苷 A 显著抑制 DSS 诱导的体重减轻和结肠长度缩短。柴胡皂苷 A 还可预防 DSS 诱导的结肠组织学改变和 MPO 活性。TNF-α 和 IL-1ß 的水平因 DSS 而增加，并被柴胡皂苷 A 呈剂量依赖性抑制。此外，柴胡皂苷 A 可显著抑制 DSS 诱导的 NF-κB 激活并上调 LXRα 的表达。综上所述，我们的结果表明柴胡皂苷 A 对 DSS 诱导的结肠炎具有保护作用。柴胡皂苷 A 通过抑制炎症反应来保护 DSS 诱导的结肠炎。
Zotero 插件