基因突变携带者：乳腺癌和卵巢癌筛查指南及影像学考虑因素。
Mutation Carriers: Breast and Ovarian Cancer Screening Guidelines and Imaging Considerations.
机构信息
From the Department of Radiology (M.E., E.S.), Department of Obstetrics and Gynecology (B.L., E.S.), Division of Gynecologic Oncology (L.B.), Department of Medicine (K.B.W.), Carbone Comprehensive Cancer Center (K.B.W.), Department of Family Medicine and Community Health (S.S.), and Department of Surgery (L.G.W.), University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252; Department of Radiology and Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor, Mich (K.E.M.).
出版信息
Radiology. 2019 Jun;291(3):554-569. doi: 10.1148/radiol.2019181814. Epub 2019 Apr 30.
Patients who carry the 1 and 2 gene mutations have an underlying genetic predisposition for breast and ovarian cancers. These deleterious genetic mutations are the most common genes implicated in hereditary breast and ovarian cancers. This monograph summarizes the evidence behind current screening recommendations, reviews imaging protocols specific to this patient population, and illustrates some of the imaging nuances of breast and ovarian cancers in this clinical setting.
携带 1 和 2 基因突变的患者存在乳腺癌和卵巢癌的遗传易感性。这些有害的基因突变是遗传性乳腺癌和卵巢癌中最常见的基因。本专论总结了当前筛查建议背后的证据，回顾了针对这一患者群体的特定影像学方案，并说明了在这种临床情况下乳腺癌和卵巢癌的一些影像学特征。
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