联合定量 F-FDG PET/CT 和 DW-MRI 参数预测鼻窦恶性肿瘤的生存情况。
Prediction of survival with combining quantitative F-FDG PET/CT and DW-MRI parameters in sinonasal malignancies.
机构信息
Department of Radiology, University of Minnesota Medical Center, Fairview, Minneapolis, Minnesota.
Department of Otolaryngology-Head and Neck Surgery, University of Minnesota Medical Center, Fairview, Minneapolis, Minnesota.
出版信息
Head Neck. 2019 Sep;41(9):3080-3089. doi: 10.1002/hed.25799. Epub 2019 Apr 30.
BACKGROUND
We aimed to establish the prognostic value of F-fluoro-deoxy-glucose positron emission/CT ( F-FDG PET/CT) and diffusion-weighted (DW) MRI in determining overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) of sinonasal malignancies.
METHODS
Sixty-eight patients with sinonasal cancer who underwent both pretreatment F-FDG PET/CT scan and head-neck MRI from January 2009 through August 2017 were retrospectively reviewed. Kaplan-Meier survival analysis of F-FDG PET/CT and DW-MRI parameters were performed for OS, PFS, and DMFS.
RESULTS
Cox regression analysis determined that all the quantitative F-FDG PET/CT and DW-MRI parameters were independently correlated with PFS, DMFS, and OS (P < .05). After controlling for imaging variables, perineural invasion (P = .02) and ill-defined margin (P = .02) were found to be significantly correlated with shorter OS; while the perineural invasion was significantly correlated with shorter PFS (P = .02).
CONCLUSIONS
The pretreatment DW-MRI and F-FDG PET/CT parameters could be substantial surrogate markers for sinonasal malignancies.
背景
我们旨在确定 F-氟代脱氧葡萄糖正电子发射/CT（ F-FDG PET/CT）和弥散加权（DW）MRI 在确定鼻窦恶性肿瘤的总生存期（OS）、无进展生存期（PFS）和无远处转移生存期（DMFS）方面的预后价值。
方法
回顾性分析了 2009 年 1 月至 2017 年 8 月期间接受了两种预处理 F-FDG PET/CT 扫描和头颈部 MRI 的 68 例鼻窦癌患者。对 F-FDG PET/CT 和 DW-MRI 参数进行 Kaplan-Meier 生存分析，以评估 OS、PFS 和 DMFS。
结果
Cox 回归分析确定所有定量 F-FDG PET/CT 和 DW-MRI 参数与 PFS、DMFS 和 OS 独立相关（P <.05）。在控制了影像学变量后，发现神经周围侵犯（P =.02）和边界不清晰（P =.02）与较短的 OS 显著相关；而神经周围侵犯与较短的 PFS 显著相关（P =.02）。
结论
预处理 DW-MRI 和 F-FDG PET/CT 参数可以作为鼻窦恶性肿瘤的重要替代标志物。
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