新生儿狼疮中右心室血栓形成：病例报告。

Right ventricular thrombus in a case of neonatal lupus: case report.

机构信息

1 Department of Rheumatology, Rehabilitation and Physical Medicine, Benha University, Egypt.

2 Department of Rheumatology, Al Hada Armed Forces Hospital, Taif, KSA.

出版信息

Lupus. 2019 May;28(6):783-785. doi: 10.1177/0961203319846384. Epub 2019 May 1.

DOI:10.1177/0961203319846384

PMID:31042125

Abstract

Neonatal thrombosis is considered a rare manifestation with unclear aetiology. We reported a neonatal lupus of a Sjogren's syndrome mother with recurrent miscarriage secondary to antiphospholipid syndrome; seronegative to anticardiolipin antibodies, lupus anticoagulant and B2GP1. She was serologically positive to antiphosphatidylethanolamine and antiprothrombin antibodies, anti-SSA/Ro and anti-SSB/La. The neonate developed neonatal lupus complicated with right ventricular thrombus assumed to be induced by maternal transmission of antiphosphatidylethanolamine and antiprothrombin antibodies, treated successfully with tissue plasminogen activator and warfarin.

摘要

新生儿血栓形成被认为是一种罕见的表现，其病因尚不清楚。我们报告了一例由抗磷脂综合征引起复发性流产的干燥综合征母亲的新生儿狼疮；抗心磷脂抗体、狼疮抗凝物和 B2GP1 均为阴性。她的血清学检查结果为抗磷脂酰乙醇胺和抗凝血酶原抗体、抗 SSA/Ro 和抗 SSB/La 阳性。新生儿发生了新生儿狼疮，伴有右心室血栓形成，据推测是由母亲抗磷脂酰乙醇胺和抗凝血酶原抗体的传递引起的，经组织型纤溶酶原激活物和华法林治疗后成功治愈。