表皮脂质：特应性皮炎发病机制的关键介质。
Epidermal Lipids: Key Mediators of Atopic Dermatitis Pathogenesis.
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA; Knight Cancer Institute, Portland, OR 97239, USA.
出版信息
Trends Mol Med. 2019 Jun;25(6):551-562. doi: 10.1016/j.molmed.2019.04.001. Epub 2019 May 1.
Abstract
The skin barrier keeps the 'inside in' and the 'outside out', forming a protective blanket against external insults. Epidermal lipids, such as ceramides, fatty acids (FAs), triglycerides, and cholesterol, are integral components driving the formation and maintenance of the epidermal permeability barrier (EPB). A breach in this lipid barrier sets the platform for the subsequent onset and progression of atopic dermatitis (AD). Such lipids are also important in the normal functioning of organisms, both plants and animals, and in diseases, including cancer. Given the doubling of the number of cases of AD in recent years and the chronic nature of this disorder, here we shed light on the multifaceted role of diverse types of lipid in mediating AD pathogenesis.
摘要
皮肤屏障可防止有害物质进入体内和体表水分流失，为人体形成抵御外界刺激的保护屏障。表皮脂质，如神经酰胺、脂肪酸 (FA)、甘油三酯和胆固醇，是形成和维持表皮通透性屏障 (EPB) 的重要组成部分。该脂质屏障一旦遭到破坏，就为特应性皮炎 (AD) 的后续发生和发展提供了平台。这些脂质在动植物的正常生理功能以及包括癌症在内的疾病中也发挥着重要作用。鉴于近年来 AD 病例数增加了一倍，且该疾病具有慢性特征，因此我们在此强调了不同类型的脂质在介导 AD 发病机制方面的多效性作用。
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