Bulska-Będkowska Weronika, Chełmecka Elżbieta, Owczarek Aleksander J, Mizia-Stec Katarzyna, Witek Andrzej, Szybalska Aleksandra, Grodzicki Tomasz, Olszanecka-Glinianowicz Magdalena, Chudek Jerzy
Department of Internal Diseases and Oncological Chemotherapy, School of Medicine in Katowice, Medical University of Silesia, 40-027 Katowice, Poland.
Department of Statistics, Department of Instrumental Analysis, School of Pharmacy and Laboratory Medicine in Sosnowiec, Medical University of Silesia, 41-200 Sosnowiec, Poland.
J Clin Med. 2019 May 3;8(5):607. doi: 10.3390/jcm8050607.
(1) Background: Cancer antigen 125 (CA125) is a glycoprotein that is expressed by tissue derived from coelomic epithelium in the pleura, peritoneum, pericardium. It has been shown that CA125 concentrations are correlated with NT-proBNP in older with congestive heart failure (HF). We conducted a study on the association between concentrations of CA125 and NT-proBNP in a population-based cohort of older Polish women. (2) Methods: The current research is sub-study of a large, cross-sectional research project (PolSenior). The study group consisted of 1565 Caucasian women aged 65-102 years. To assess the relationship between CA125 and other variables a stepwise backward multivariate normal and skew-t regression analyses were performed. (3) Results: The median of CA125 concentration was 13.0 U/mL and values over the upper normal range limit (35 U/mL) were observed in 5.1% ( = 79) of the study cohort. The concentration of CA125 was positively related to age, hospitalization for HF and history of atrial fibrillation and chronic obstructive pulmonary disease, levels of NT-proBNP, IL-6, hs-CRP and triglycerides. We found, in multivariate analyses, that increased CA125 levels were independently associated with log (IL-6) (β = 11.022), history of hospitalization for HF (β = 4.619), log (NT-proBNP) (β = 4.416) and age (β = 3.93 for 10 years). (4) Conclusion: Despite the association between CA125 and NT-proBNP, the usefulness of CA125 for the detection of HF in older women is limited by factors such as inflammatory status and age.
(1) 背景：癌抗原125（CA125）是一种糖蛋白，由胸膜、腹膜、心包膜的体腔上皮衍生组织表达。研究表明，在老年充血性心力衰竭（HF）患者中，CA125浓度与N末端脑钠肽前体（NT-proBNP）相关。我们对波兰老年女性人群中CA125和NT-proBNP浓度之间的关联进行了一项研究。(2) 方法：当前研究是一个大型横断面研究项目（PolSenior）的子研究。研究组由1565名年龄在65至102岁之间的白种女性组成。为评估CA125与其他变量之间的关系，进行了逐步向后多变量正态和偏态t回归分析。(3) 结果：CA125浓度的中位数为13.0 U/mL，在5.1%（n = 79）的研究队列中观察到值超过正常范围上限（35 U/mL）。CA125浓度与年龄、因HF住院、房颤和慢性阻塞性肺疾病病史、NT-proBNP、白细胞介素-6（IL-6）、高敏C反应蛋白（hs-CRP）和甘油三酯水平呈正相关。我们在多变量分析中发现，CA125水平升高与log(IL-6)（β = 11.022）、因HF住院史（β = 4.619）、log(NT-proBNP)（β = 4.416）和年龄（每10年β = 3.93）独立相关。(4) 结论：尽管CA125与NT-proBNP之间存在关联，但CA125在老年女性中用于检测HF的效用受到炎症状态和年龄等因素的限制。
