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Genetic Evidence That Naive T Cells Can Contribute Significantly to the Human Immunodeficiency Virus Intact Reservoir: Time to Re-evaluate Their Role.

作者信息

Venanzi Rullo Emmanuele, Cannon LaMont, Pinzone Marilia Rita, Ceccarelli Manuela, Nunnari Giuseppe, O'Doherty Una

机构信息

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia.

Department of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Italy.

出版信息

Clin Infect Dis. 2019 Nov 27;69(12):2236-2237. doi: 10.1093/cid/ciz378.

DOI:10.1093/cid/ciz378
PMID:31063189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6880327/
Abstract
摘要

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本文引用的文献

1
Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion.纵向 HIV 测序揭示了潜伏库表达导致衰减，而这种衰减被克隆扩增所掩盖。
Nat Commun. 2019 Feb 13;10(1):728. doi: 10.1038/s41467-019-08431-7.
2
Naive CD4+ T Cells Harbor a Large Inducible Reservoir of Latent, Replication-competent Human Immunodeficiency Virus Type 1.初始CD4+ T细胞中存在大量可诱导的潜伏性、具有复制能力的1型人类免疫缺陷病毒储存库。
Clin Infect Dis. 2019 Nov 13;69(11):1919-1925. doi: 10.1093/cid/ciz108.
3
Identification of Genetically Intact HIV-1 Proviruses in Specific CD4 T Cells from Effectively Treated Participants.在有效治疗的参与者的特定 CD4 T 细胞中鉴定遗传完整的 HIV-1 前病毒。
Cell Rep. 2017 Oct 17;21(3):813-822. doi: 10.1016/j.celrep.2017.09.081.
4
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.HIV储存库的大小和持久性由T细胞存活和稳态增殖驱动。
Nat Med. 2009 Aug;15(8):893-900. doi: 10.1038/nm.1972. Epub 2009 Jun 21.
5
Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells.人类免疫缺陷病毒直接整合到初始静止CD4+T细胞中，但进入初始细胞的效率低于记忆细胞。
J Virol. 2009 May;83(9):4528-37. doi: 10.1128/JVI.01910-08. Epub 2009 Feb 11.