Shum A Y, Chen C S, Hsu S C, Chen C F
Neurosci Lett. 1987 Mar 31;75(2):223-8. doi: 10.1016/0304-3940(87)90301-6.
Turnover rates, as estimated from the accumulation of the intermediates, 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition, were used to investigate the relationship between central catecholaminergic and serotonergic neurons and the development of hypertension in the one-kidney, one-clip renal hypertensive rats. Results indicated that at one week following clipping, 5-HTP accumulation was decreased in the posterior hypothalamus. At 5 weeks no changes were observed. At 20 weeks higher accumulations of both DOPA and 5-HTP were observed in the medulla oblongata while in the anterior hypothalamus DOPA accumulation was increased.
通过抑制脱羧酶后中间产物3,4-二羟基苯丙氨酸（DOPA）和5-羟色氨酸（5-HTP）的积累来估计的周转率，被用于研究单肾单夹肾性高血压大鼠中枢儿茶酚胺能和5-羟色胺能神经元之间的关系以及高血压的发展。结果表明，夹闭后1周，下丘脑后部5-HTP的积累减少。5周时未观察到变化。20周时，在延髓中观察到DOPA和5-HTP的积累均增加，而在下丘脑前部，DOPA的积累增加。
