轴突利用 190RhoGAP 导航噪声。
Axons Navigate Noise with 190RhoGAP.
机构信息
Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, the Netherlands.
Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, the Netherlands.
出版信息
Neuron. 2019 May 8;102(3):512-514. doi: 10.1016/j.neuron.2019.04.024.
In this issue of Neuron, Bonanomi et al. (2019) investigate how navigating axons ignore irrelevant guidance signals. They show that the binding of p190RhoGAP to DCC suppresses inappropriate responses to Netrin-1, allowing motor axons to exit the embryonic spinal cord.
在本期《神经元》中，Bonanomi 等人（2019 年）研究了导向轴突如何忽略不相关的导向信号。他们表明，p190RhoGAP 与 DCC 的结合抑制了对 Netrin-1 的不适当反应，从而使运动轴突离开胚胎脊髓。
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