左心室辅助装置相关心内膜炎涉及金黄色葡萄球菌的多个克隆，具有不同的抗菌药物敏感性模式。
Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns.
机构信息
Department of Infectious Diseases, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan; Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
出版信息
Int J Infect Dis. 2019 Jul;84:44-47. doi: 10.1016/j.ijid.2019.05.001. Epub 2019 May 7.
The case of a patient with left ventricular assist device (LVAD)-associated endocarditis involving multiple clones of Staphylococcus aureus is presented. Different clones with distinct colony morphology were identified from blood cultures collected on the same day and showed diverse antimicrobial resistance patterns. In addition, a difference in antimicrobial susceptibility was observed even within an identical clone recovered 400 days apart due to the loss of SCCmec for methicillin and modification of the 23S rRNA target site for linezolid during a long-term treatment course.
现介绍一例左心室辅助装置（LVAD）相关心内膜炎患者，该患者感染了多种金黄色葡萄球菌克隆。从同一天采集的血培养中鉴定出不同形态的不同克隆，并表现出不同的抗生素耐药模式。此外，即使在相隔 400 天的同一克隆中，也观察到抗生素敏感性存在差异，这是由于长期治疗过程中 SCCmec 对甲氧西林的丢失和 23S rRNA 靶位对利奈唑胺的修饰。
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