Abi-Gerges Najah, McMahon Carrie, Vargas Hugo, Sager Philip, Chui Ray, Stevens Dale, Davila Jonathan, Schaub Johanna R, Wu Joseph C, Del Rio Carlos, Mathes Chris, Miller Paul E, Burns-Naas Leigh Ann, Ghetti Andre
AnaBios Corporation, San Diego, CA 92109, USA.
Gilead Sciences, Inc., Foster City, CA 94404, USA.
J Pharmacol Toxicol Methods. 2019 Jul-Aug;98:106582. doi: 10.1016/j.vascn.2019.106582. Epub 2019 May 9.
The Safety Pharmacology Society (SPS) held a West Coast Regional Meeting in Foster City, CA on November 14, 2018 at the Gilead Sciences Inc. site. The meeting was attended by scientists from the pharmaceutical and biotechnology industry, contract research organizations (CROs) and academia. A variety of scientific topics were presented by speakers, covering a broad variety of topics in the fields of safety risk assessment; from pro-arrhythmia and contractility risk evaluation, to models of heart failure and seizure in-a-dish; and discovery sciences; from stem cells and precision medicine, to models of inherited cardiomyopathy and precision cut tissue slices. The present review summarizes the highlights of the presentations and provides an overview of the high level of innovation currently underlying many frontiers in safety pharmacology.
安全药理学协会（SPS）于2018年11月14日在加利福尼亚州福斯特城的吉利德科学公司所在地召开了一次西海岸地区会议。制药和生物技术行业、合同研究组织（CRO）以及学术界的科学家出席了此次会议。演讲者介绍了各种科学主题，涵盖安全风险评估领域的广泛话题；从心律失常和收缩性风险评估，到心力衰竭和盘中癫痫模型；以及发现科学领域；从干细胞和精准医学，到遗传性心肌病模型和精密切割组织切片。本综述总结了演讲的要点，并概述了当前安全药理学许多前沿领域所蕴含的高水平创新。
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