转移性胃癌患者胃空肠吻合术与胃切除术临床结局的比较
Comparison of Clinical Outcomes of Gastrojejunal Bypass and Gastrectomy in Patients With Metastatic Gastric Cancer.
作者信息
Matsubara Daiki, Konishi Hirotaka, Kubota Takeshi, Kosuga Toshiyuki, Shoda Katsutoshi, Shiozaki Atsushi, Fujiwara Hitoshi, Okamoto Kazuma, Otsuji Eigo
机构信息
Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
出版信息
Anticancer Res. 2019 May;39(5):2545-2551. doi: 10.21873/anticanres.13376.
BACKGROUND/AIM: Surgical therapy for stage IV gastric cancer patients is still debatable. The clinical outcomes were compared between gastrojejunal bypass and gastrectomy for metastatic gastric cancer patients.
PATIENTS AND METHODS
A total of 110 patients with metastatic gastric cancer who underwent surgery were retrospectively analyzed. Twenty-nine patients underwent gastrojejunal bypass (group B) and 81 underwent gastrectomy (group G).
RESULTS
There was no significant difference in the 3-year overall survival between Group G patients with partial gastrectomy and total gastrectomy. However, patients in group G had a significantly better prognosis compared to patients in group B (p=0.01 and 0.03, respectively). The prognosis of patients with postoperative chemotherapy was significantly better in group G compared to group B (p=0.03), whereas it was not significantly different for the patients without postoperative chemotherapy (p=0.24).
CONCLUSION
Gastrectomy in patients with metastatic gastric cancer may improve survival when combined with postoperative chemotherapy.
背景/目的：IV期胃癌患者的手术治疗仍存在争议。对转移性胃癌患者行胃空肠吻合术和胃切除术的临床结果进行比较。
患者与方法
回顾性分析110例行手术治疗的转移性胃癌患者。29例行胃空肠吻合术（B组），81例行胃切除术（G组）。
结果
G组中行部分胃切除术和全胃切除术的患者3年总生存率无显著差异。然而，G组患者的预后明显优于B组患者（分别为p=0.01和0.03）。G组术后化疗患者的预后明显优于B组（p=0.03），而未进行术后化疗的患者预后无显著差异（p=0.24）。
结论
转移性胃癌患者行胃切除术联合术后化疗可能提高生存率。
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