Department of Nutrition, College of Rehabilitation, Kasprzaka 49, 01-234 Warsaw, Poland.
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Molecules. 2019 May 15;24(10):1873. doi: 10.3390/molecules24101873.
Recently, the fast development of hybrid nanogels dedicated to various applications has been seen. In this context, nanogels incorporating biomolecules into their nanonetworks are promising innovative carriers that gain great potential in biomedical applications. Hybrid nanogels containing various types of biomolecules are exclusively designed for: improved and controlled release of drugs, targeted delivery, improvement of biocompatibility, and overcoming of immunological response and cell self-defense. This review provides recent advances in this rapidly developing field and concentrates on: (1) the key physical consequences of using hybrid nanogels and introduction of biomolecules; (2) the construction and functionalization of degradable hybrid nanogels; (3) the advantages of hybrid nanogels in controlled and targeted delivery; and (4) the analysis of the specificity of drug release mechanisms in hybrid nanogels. The limitations and future directions of hybrid nanogels in targeted specific- and real-time delivery are also discussed.
近年来，专门用于各种应用的杂化纳米凝胶发展迅速。在这种情况下，将生物分子纳入纳米网络的纳米凝胶是很有前途的创新载体，在生物医学应用中具有巨大的潜力。含有各种类型生物分子的杂化纳米凝胶专为以下目的而设计：改善和控制药物释放、靶向递送、提高生物相容性、克服免疫反应和细胞自我防御。本综述提供了该快速发展领域的最新进展，并集中讨论了：（1）使用杂化纳米凝胶和引入生物分子的关键物理后果；（2）可降解杂化纳米凝胶的构建和功能化；（3）杂化纳米凝胶在控制和靶向递送上的优势；（4）分析杂化纳米凝胶中药物释放机制的特异性。还讨论了杂化纳米凝胶在靶向特定和实时递送上的局限性和未来方向。
