DNAzyme 激活的蛋白支架 CRISPR-Cas9 纳米组装体用于基因组编辑。

DNAzyme activated protein-scaffolded CRISPR-Cas9 nanoassembly for genome editing.

机构信息

Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.

出版信息

Chem Commun (Camb). 2019 Jun 11;55(46):6511-6514. doi: 10.1039/c9cc03172c. Epub 2019 May 17.

DOI:10.1039/c9cc03172c

PMID:31099367

Abstract

A novel self-assembled protein-scaffolded CRISPR-Cas9 nanosystem for facile and efficient gene editing in a DNAzyme-controlled manner has been developed.

摘要

一种新型的自组装蛋白支架 CRISPR-Cas9 纳米系统，通过 DNAzyme 控制的方式，实现了简便高效的基因编辑。