DNA 损伤的转录反应。
Transcriptional responses to DNA damage.
机构信息
Department of Medicine, University of California San Diego, La Jolla, California, USA; Biomedical Sciences Program, University of California San Diego, La Jolla, California, USA.
Department of Medicine, University of California San Diego, La Jolla, California, USA; Biomedical Sciences Program, University of California San Diego, La Jolla, California, USA; Program in Bioinformatics, University of California San Diego, La Jolla, California, USA; Department of Bioengineering, University of California San Diego, La Jolla, California, USA.
出版信息
DNA Repair (Amst). 2019 Jul;79:40-49. doi: 10.1016/j.dnarep.2019.05.002. Epub 2019 May 7.
In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage. We review differences in observed transcriptional responses as a function of cell cycle stage and emphasize the importance of experimental design in these transcriptional response studies. We additionally consider topics including structural challenges in the transcriptional response to DNA damage as well as the connection between transcription and protein abundance.
针对 DNA 损伤的威胁，细胞表现出一种显著的、多因素的反应，从转录变化到蛋白质修饰，统称为 DNA 损伤反应 (DDR)。在这里，我们回顾了与 DNA 损伤的转录反应相关的文献。我们综述了观察到的转录反应随细胞周期阶段的变化，并强调了这些转录反应研究中实验设计的重要性。我们还考虑了包括 DNA 损伤转录反应中的结构挑战以及转录和蛋白质丰度之间的联系等主题。
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