外部三叉神经刺激：一项长期随访研究。

External trigeminal nerve stimulation: A long term follow up study.

机构信息

Hospital Universitario Fundación Jiménez Díaz and Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.

MECBA (Instituto de Medicina y Cirugía de Barcelona), Barcelona, Spain.

出版信息

Seizure. 2019 Jul;69:218-220. doi: 10.1016/j.seizure.2019.01.022. Epub 2019 Jan 24.

DOI:10.1016/j.seizure.2019.01.022

PMID:31108410

Abstract

PURPOSE

External trigeminal nerve stimulation is an emerging noninvasive therapy for drug resistant epilepsy (DRE). The aim of this study is to describe the long-term outcome of a series of patients treated with eTNS.

METHODS

We present a retrospective observational study of patients with DRE who received eTNS treatment, comparing the monthly seizure frequency during the 3-months period before eTNS initiation with the monthly seizure frequency at 6, 12, 24, 36 and 48 months after eTNS. We analyze the responder rate, the retention rate and the tolerability.

RESULTS

17 patients with highly drug-resistant epilepsy were included. Mean follow-up was 2194 [6-56] months. The responder rate was 35% at 6 months and 12 months, 23% at 24 months, 19% at 36 months, and 14% at 48 months. Retention rates at the same periods were 88%, 53%, 41%, 37.5% and 28.5%. There were no reports of serious adverse events. Four patients reported improvement in sleep and better mood.

CONCLUSION

The effectivity of eTNS is similar to some of the new treatments available, with a retention rate of 52% in the first year and 285% at 4 years. Tolerability is excellent with only mild effects reported by a minority of patients.

摘要

目的

外部三叉神经刺激是一种新兴的治疗耐药性癫痫（DRE）的非侵入性疗法。本研究的目的是描述一系列接受 eTNS 治疗的患者的长期结果。

方法

我们进行了一项回顾性观察研究，纳入了接受 eTNS 治疗的 DRE 患者，比较了 eTNS 治疗前 3 个月的每月癫痫发作频率与 eTNS 治疗后 6、12、24、36 和 48 个月的每月癫痫发作频率。我们分析了应答率、保留率和耐受性。

结果

共纳入 17 例药物难治性癫痫患者。平均随访时间为 2194[6-56]个月。6 个月和 12 个月时的应答率为 35%，24 个月时为 23%，36 个月时为 19%，48 个月时为 14%。同期的保留率分别为 88%、53%、41%、37.5%和 28.5%。无严重不良事件报告。4 例患者报告睡眠改善和情绪改善。