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分娩后继发性小头畸形的发生:寨卡病毒母婴经母乳传播的可能后果

Development of Secondary Microcephaly After Delivery: Possible Consequence of Mother-Baby Transmission of Zika Virus in Breast Milk.

作者信息

Siqueira Mello Alexandra, Pascalicchio Bertozzi Ana Paula A, Rodrigues Maria Manoela D, Gazeta Rosa Estela, Moron Antônio F, Soriano-Arandes Antoni, Sarmento Stéphanno Gomes Pereira, Vedovello Danila, Silva Andrea Cristina B, Grillo Fajardo Thamirys C, Witkin Steven S, Passos Saulo D

机构信息

Laboratory of Pediatric Infectology, Department of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil.

Department of Pediatrics, Jundiaí School of Medicine, São Paulo, SP, Brazil.

出版信息

Am J Case Rep. 2019 May 21;20:723-725. doi: 10.12659/AJCR.915726.

Abstract

BACKGROUND The Zika virus is an arbovirus that has as main source of transmission the bite of infected insects of the genus Aedes and has been associated with cases of congenital malformation and microcephaly in neonates. However, other sources of transmission have been identified since the emergence of this virus in the world population, such as vertical transmission by semen and possibly other body fluids such as vaginal secretion and breast milk. CASE REPORT An infant, born to a mother whose previous delivery was a baby with severe microcephaly, was normal and was negative for Zika virus at birth but developed secondary microcephaly 1 month later, that persisted. The baby was exclusively breast-fed and Zika virus was present in the mother's milk. CONCLUSIONS We report the detection of Zika virus exclusively in the breast milk of a woman after her second delivery of an infant, who later developed microcephaly. This case is consistent with possible vertical transmission.

摘要

背景

寨卡病毒是一种虫媒病毒,主要传播源是被感染的伊蚊叮咬,且与新生儿先天性畸形和小头畸形病例有关。然而,自该病毒在全球人群中出现以来,已确定了其他传播源,如精液的垂直传播以及可能通过其他体液传播,如阴道分泌物和母乳。病例报告:一名婴儿的母亲之前分娩的婴儿患有严重小头畸形,该婴儿出生时正常,出生时寨卡病毒检测呈阴性,但1个月后出现继发性小头畸形且持续存在。该婴儿纯母乳喂养,母乳中存在寨卡病毒。结论:我们报告了一名妇女在第二次分娩后,其母乳中仅检测到寨卡病毒,而该婴儿后来出现了小头畸形。该病例符合可能的垂直传播情况。

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