Soto-Rivera Carmen L, Agus Michael S D
Divisions of Endocrinology and Medicine Critical Care, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
J Pediatr Intensive Care. 2016 Dec;5(4):198-204. doi: 10.1055/s-0036-1583281. Epub 2016 May 11.
Hyperglycemia is a common complication in critically ill, nondiabetic children. Four large pediatric randomized controlled trials of tight glycemic control (TGC) have been conducted to date with contradicting results. This review will highlight the design and outcomes of these trials and other relevant studies to provide an overview of the advantages and disadvantages of TGC for different populations at risk of hyperglycemia along with future directions for research.
高血糖是危重症非糖尿病儿童常见的并发症。迄今为止,已开展了四项关于严格血糖控制(TGC)的大型儿科随机对照试验,结果相互矛盾。本综述将重点介绍这些试验及其他相关研究的设计与结果,以概述TGC对不同高血糖风险人群的优缺点,并提出未来的研究方向。