钯催化芳基碘化物和内炔烃的羰基化合成取代环戊烯酮。

Palladium-catalyzed carbonylative synthesis of substituted cyclopentenones from aryl iodides and internal alkynes.

机构信息

Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou 310018, People's Republic of China.

出版信息

Org Biomol Chem. 2019 Jun 18;17(24):5882-5885. doi: 10.1039/c9ob01019j.

Abstract

In this Communication, a palladium-catalyzed carbonylative synthesis of substituted cyclopentenones has been developed. With aryl iodides and internal alkynes as the substrates, via a domino process consisting of a formal Pauson-Khand reaction, good yields of the desired products were obtained. Interestingly, formic acid has been used both as a hydrogen source and a carbon monoxide source in this system.

摘要

在本通讯中，开发了一种钯催化的取代环戊烯酮的羰基化合成方法。以芳基碘化物和内部炔烃为底物，通过包含形式的 Pauson-Khand 反应的多步反应过程，得到了所需产物的良好收率。有趣的是，在该体系中，甲酸既可用作氢源又可用作一氧化碳源。