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旱莲草的植物化学与神经保护作用

Phytochemistry and neuroprotective effects of Eclipta alba (L.) Hassk.

作者信息

Guenné Samson, Ouattara Nabèrè, Ouédraogo Noufou, Ciobica Alin, Hilou Adama, Kiendrebéogo Martin

机构信息

Laboratory of Applied Biochemistry and Chemistry (LA.BIO.C.A), University Ouaga I Pr Joseph KI-ZERBO, 03 P.O. Box: 7021, Ouagadougou 03, Burkina Faso.

University of Dedougou, BP 176, Dedougou, Burkina Faso.

出版信息

J Complement Integr Med. 2019 May 21;17(1):/j/jcim.2019.17.issue-1/jcim-2019-0026/jcim-2019-0026.xml. doi: 10.1515/jcim-2019-0026.

Abstract

Eclipta alba (L.) Hassk. or Eclipta prostrata (Linn.) or Eclipta erecta (Linn.) is an herbaceous plant well known in Asian as African traditional medicines. These extracts are used in traditional medicine for treatment of microbial diseases and certain metabolic disorders. This review aimed to investigate phytochemical profile and neuroprotective effects of E. alba (L.) Hassk. Several compounds belonging to the families of phenolics, alkaloids, terpenoids and polysaccharides have been isolated, identified or characterized from E. alba extracts. This plant has a diverse neuropharmacological profile. Thus, its extract improves cognitive deficits and also attenuated epileptic seizures. Phytomolecules implicated in these potentials are Eclalbasaponin II and luteolin, respectively. This document updates isolated and identified organic compounds from the extracts of E. alba and reviews their neuropharmacological activities.

摘要

旱莲草(Eclipta alba (L.) Hassk.)、鳢肠(Eclipta prostrata (Linn.))或直立旱莲草(Eclipta erecta (Linn.))是一种在亚洲作为非洲传统药物而闻名的草本植物。这些提取物在传统医学中用于治疗微生物疾病和某些代谢紊乱。本综述旨在研究旱莲草(Eclipta alba (L.) Hassk.)的植物化学特征和神经保护作用。已从旱莲草提取物中分离、鉴定或表征了几种属于酚类、生物碱、萜类和多糖类的化合物。这种植物具有多种神经药理学特性。因此,其提取物可改善认知缺陷并减轻癫痫发作。涉及这些潜力的植物分子分别是旱莲草皂苷II和木犀草素。本文更新了从旱莲草提取物中分离和鉴定的有机化合物,并综述了它们的神经药理学活性。

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