住院期间发生碳青霉烯类耐药感染的可能性。
The Likelihood of Developing a Carbapenem-Resistant Infection during a Hospital Stay.
机构信息
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Antimicrob Agents Chemother. 2019 Jul 25;63(8). doi: 10.1128/AAC.00757-19. Print 2019 Aug.
Abstract
Of 1,455 unique patients in U.S. intensive care units (ICUs), 4% were rectally colonized with CRE on admission. A total of 297 patients were initially negative for carbapenem-resistant (CRE) and remained in the ICU long enough to contribute additional swabs; 22% of these patients had a subsequent CRE-positive swab, with a median time to CRE colonization of 13 days (interquartile range, 7 to 21 days). Patients colonized with carbapenemase-producing CRE were more likely than those colonized with non-carbapenemase-producing CRE to develop CRE infections during their hospitalizations (36% versus 3%; < 0.05).
摘要
在 1455 名入住美国重症监护病房（ICU）的患者中，有 4%的患者在入院时直肠定植了 CRE。共有 297 名患者最初对碳青霉烯类耐药的 CRE 呈阴性，并在 ICU 中停留足够长的时间以提供额外的拭子；其中 22%的患者随后的 CRE 拭子呈阳性，定植 CRE 的中位时间为 13 天（四分位距，7 至 21 天）。与定植非产碳青霉烯酶 CRE 的患者相比，定植产碳青霉烯酶 CRE 的患者在住院期间更有可能发生 CRE 感染（36%比 3%；<0.05）。
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