肿瘤浸润淋巴细胞在黑色素瘤中的预后价值：一项系统评价和荟萃分析。
Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis.
作者信息
Fu Qiaofen, Chen Nan, Ge Chunlei, Li Ruilei, Li Zhen, Zeng Baozhen, Li Chunyan, Wang Ying, Xue Yuanbo, Song Xin, Li Heng, Li Gaofeng
机构信息
Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan, People's Republic China.
Department of Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan, People's Republic China.
出版信息
Oncoimmunology. 2019 Apr 3;8(7):1593806. doi: 10.1080/2162402X.2019.1593806. eCollection 2019.
Tumor-infiltrating lymphocytes (TILs) are associated with prognosis in various tumors. However, it remains controversial whether the presence of TILs is related to an improved prognosis in melanoma. This meta-analysis confirmed the favorable prognostic role of the CD3+, CD4+, CD8+, FOXP3+, and CD20+ TILs in the overall survival of melanoma patients and found an association between the TILs present and improved overall survival. Additionally, subgroup analysis demonstrated that brisk TILs were obviously associated with OS, RFS and DSS/MSS. Thus, TILs may be a predictive biomarker in melanoma. This analysis will provide more insight into the study of TILs and predictive biomarker.
肿瘤浸润淋巴细胞（TILs）与多种肿瘤的预后相关。然而，TILs的存在是否与黑色素瘤预后改善相关仍存在争议。这项荟萃分析证实了CD3 +、CD4 +、CD8 +、FOXP3 +和CD20 + TILs在黑色素瘤患者总生存中的良好预后作用，并发现存在的TILs与总生存改善之间存在关联。此外，亚组分析表明活跃的TILs明显与总生存、无复发生存和疾病特异性生存/无远处转移生存相关。因此，TILs可能是黑色素瘤的一种预测生物标志物。该分析将为TILs和预测生物标志物的研究提供更多见解。
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