原发性闭角型青光眼患者静息状态下功能连接密度的改变
Altered functional connectivity density in primary angle-closure glaucoma patients at resting-state.
作者信息
Chen Linglong, Li Shenghong, Cai Fengqin, Wu Lin, Gong Honghan, Pei Chonggang, Zhou Fuqing, Zeng Xianjun
机构信息
Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang 330006, China.
Department of Ophthalmology, The First Affiliated Hospital, Nanchang University, Nanchang 330006, China.
出版信息
Quant Imaging Med Surg. 2019 Apr;9(4):603-614. doi: 10.21037/qims.2019.04.13.
BACKGROUND
Primary angle-closure glaucoma (PACG) is a neurodegenerative disease. Previous structural and functional studies of functional magnetic resonance imaging (fMRI) have demonstrated widespread dysfunction of spontaneous activity in the PACG brain. In this study, we applied a data-driven graph theory approach of functional connectivity density (FCD) mapping to investigate the altered local and global functional connectivity (FC) of the cortex in PACG.
METHODS
Forty-five PACG patients (53.28±10.79 years, 17 males/28 females) and 46 well-matched healthy controls (HCs) (52.67±11.01 years,18 males/28 females) received resting-state fMRI scans. All PACG patients finished complete ophthalmologic examinations, including retinal nerve fiber layer thickness (RNFLT), intraocular pressure (IOP), average cup to disc ratio (A-C/D), and vertical cup to disc ratio (V-C/D). We calculated the between-group FCD difference for short-range and long-range in each voxel. Then, we generated the intrinsic FC of the seed region with the whole brain. Finally, correlations were investigated between FCD value of the altered regions and clinical variables.
RESULTS
PACG patients showed increased short-range FCD in the left inferior frontal gyrus (IFG)/insula/parahippocampal gyrus and right IFG/insula (P<0.05, corrected), compared with the HCs. Simultaneously, the decreased regions in short-range FCD map were the occipital/cuneus/precuneus/superior parietal/postcentral lobe (P<0.05, corrected). In the PACG groups, decreased long-range FCD was observed in the left middle frontal gyrus compared to the HC (P<0.05, corrected). RNFLT was positively correlated with decreased short-range FCD value of the occipital/cuneus/precuneus/superior parietal/postcentral lobes, and the A-C/D was negatively correlated with the increased short-range FCD value of the left IFG/insula/parahippocampal gyrus, and the right IFG/insula.
CONCLUSIONS
Our findings suggest that PACG can induce extensive brain dysfunction, and showed different spatial distribution in short- and long-range FCD.
背景
原发性闭角型青光眼（PACG）是一种神经退行性疾病。以往功能磁共振成像（fMRI）的结构和功能研究表明，PACG患者大脑中自发活动存在广泛功能障碍。在本研究中，我们应用基于数据驱动的功能连接密度（FCD）图谱的图论方法，来研究PACG患者大脑皮质局部和整体功能连接（FC）的改变。
方法
45例PACG患者（年龄53.28±10.79岁，男性17例/女性28例）和46例匹配良好的健康对照者（HCs）（年龄52.67±11.01岁，男性18例/女性28例）接受静息态fMRI扫描。所有PACG患者均完成全面的眼科检查，包括视网膜神经纤维层厚度（RNFLT）、眼压（IOP）、平均杯盘比（A-C/D）和垂直杯盘比（V-C/D）。我们计算了每个体素中短程和长程的组间FCD差异。然后，我们生成种子区域与全脑的内在FC。最后，研究了改变区域的FCD值与临床变量之间的相关性。
结果
与HCs相比，PACG患者左侧额下回（IFG）/岛叶/海马旁回和右侧IFG/岛叶的短程FCD增加（P<0.05，校正）。同时，短程FCD图谱中减少的区域为枕叶/楔叶/楔前叶/顶上叶/中央后回（P<0.05，校正）。与HCs相比，PACG组左侧额中回的长程FCD降低（P<0.05，校正）。RNFLT与枕叶/楔叶/楔前叶/顶上叶/中央后回短程FCD值降低呈正相关，A-C/D与左侧IFG/岛叶/海马旁回和右侧IFG/岛叶短程FCD值增加呈负相关。
结论
我们的研究结果表明，PACG可导致广泛的脑功能障碍，且在短程和长程FCD中表现出不同的空间分布。
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