一种平衡的行为：PHLPP2 精细调节前列腺癌中的 AKT 活性和 MYC 稳定性。
A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer.
机构信息
Cancer Program, Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
出版信息
J Cell Biol. 2019 Jun 3;218(6):1771-1772. doi: 10.1083/jcb.201904119. Epub 2019 May 15.
PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. https://doi.org/10.1083/jcb.201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.
PTEN 缺失通过维持 AKT 激活来促进前列腺肿瘤的进展。Nowak 等人（2019 年，https://doi.org/10.1083/jcb.201902048）出人意料地表明，AKT 抑制磷酸酶 PHLPP2 通过增加 MYC 稳定性促进双重 PTEN 和 p53 缺失情况下的疾病进展。
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