抗癫痫药物对遗传性全面性癫痫发作放电的影响：系统评价。
The effect of antiepileptic drugs on epileptiform discharges in genetic generalized epilepsy: A systematic review.
机构信息
St Vincent's Clinical School, The University of Melbourne, Melbourne, Australia; Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Melbourne, Australia.
Department of Medicine, St. Vincent's Hospital, The University of Melbourne, Melbourne, Australia; Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia.
出版信息
Epilepsy Behav. 2019 Jul;96:175-182. doi: 10.1016/j.yebeh.2019.04.030. Epub 2019 May 28.
OBJECTIVE
The objective of this study was to evaluate the current evidence regarding the effect of antiepileptic drugs (AEDs) on epileptiform discharge (ED) burden in genetic generalized epilepsy (GGE).
METHODS
We conducted a comprehensive literature search of PubMed, Embase, PsycINFO, and the Web of Science Core Collection databases using the keywords 'genetic generalized epilepsy', 'antiepileptic drugs' and 'epileptiform discharge'. Primary human studies published in English that reported the effect of AEDs on EDs captured on electroencephalogram (EEG) recordings of at least 24 h in duration in patients with GGE were included.
RESULTS
Six studies published between 1984 and 2017, which reported the effect of AEDs on EDs, involving a total of 116 patients with GGE, were analyzed. Our systematic review found a tendency for AEDs to reduce ED density, frequency, cumulative duration, and burst duration in GGE. Furthermore, we found evidence that the AED-mediated reduction in ED burden was associated with improved seizure control and cognitive outcomes.
CONCLUSIONS
Antiepileptic drugs tend to reduce ED burden in GGE, but the significance of this association remains uncertain.
目的
本研究旨在评估抗癫痫药物（AEDs）对遗传性全面性癫痫（GGE）癫痫样放电（ED）负担的影响的现有证据。
方法
我们使用“genetic generalized epilepsy”、“antiepileptic drugs”和“epileptiform discharge”等关键词，对 PubMed、Embase、PsycINFO 和 Web of Science Core Collection 数据库进行了全面的文献检索，纳入了发表在英文期刊上的、报告了至少 24 小时 EEG 记录中 GGE 患者 AED 对 ED 影响的人类原始研究。
结果
我们分析了 6 项发表于 1984 年至 2017 年间、共涉及 116 例 GGE 患者的研究，这些研究报告了 AED 对 ED 的影响。我们的系统综述发现，AED 倾向于降低 GGE 中的 ED 密度、频率、累积持续时间和爆发持续时间。此外，我们有证据表明，AED 介导的 ED 负担减轻与改善癫痫发作控制和认知结局相关。
结论
AED 倾向于降低 GGE 中的 ED 负担，但这种关联的意义尚不确定。
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