Ghert Michelle, Mwita Winfrida, Mandari Faiton Ndesanjo
McMaster University, Hamilton, Ontario, Canada (Dr. Ghert), and the Kilimanjaro Christian Medical School, Moshi, Tanzania (Dr. Mwita and Dr. Mandari).
J Am Acad Orthop Surg Glob Res Rev. 2019 Mar 5;3(3):e045. doi: 10.5435/JAAOSGlobal-D-17-00045. eCollection 2019 Mar.
Bone tumors account for a small fraction of childhood cancers. Most published reports are from developed countries. The purpose of this study was to review the primary bone tumors in children and adolescents treated at a referral center in Northern Tanzania. We completed a 10-year hospital-based cross-sectional study in which all patients younger than 20 years diagnosed with a primary bone tumor at the Kilimanjaro Christian Medical Center Orthopaedic Department from January 2006 to December 2015 were identified and reviewed. Of the 80 identified patients, 15 (18.8%) were aged 5 to 8 years, and 65 (81%) were aged 9 to 19 years. Forty-seven males (59%) and 33 females (41%) were identified. The most common tumor locations were the femur, tibia, and humerus. Osteosarcoma was the most common malignant diagnosis (49 patients, 61%). No cases of Ewing sarcoma were reported. The most common tribal origins of the patients were Chagga and Maasai. Most primary bone tumors treated at a referral center in Northern Tanzania are malignant, with osteosarcoma representing the vast majority. No cases of Ewing sarcoma were identified in this tertiary referral hospital-based database.
骨肿瘤在儿童癌症中占比很小。大多数已发表的报告来自发达国家。本研究的目的是回顾坦桑尼亚北部一家转诊中心治疗的儿童和青少年原发性骨肿瘤情况。我们完成了一项为期10年的基于医院的横断面研究,确定并回顾了2006年1月至2015年12月期间在乞力马扎罗基督教医疗中心骨科诊断为原发性骨肿瘤的所有20岁以下患者。在80名确诊患者中,15名(18.8%)年龄在5至8岁,65名(81%)年龄在9至19岁。确定了47名男性(59%)和33名女性(41%)。最常见的肿瘤部位是股骨、胫骨和肱骨。骨肉瘤是最常见的恶性诊断(49例,61%)。未报告尤因肉瘤病例。患者最常见的部落起源是查加族和马赛族。坦桑尼亚北部一家转诊中心治疗的大多数原发性骨肿瘤是恶性的,其中骨肉瘤占绝大多数。在这个基于三级转诊医院的数据库中未发现尤因肉瘤病例。