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A natural killer cell receptor takes sharp aim at the world of bacteria.

作者信息

Parham Peter

机构信息

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305;

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305.

出版信息

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12601-12603. doi: 10.1073/pnas.1907937116. Epub 2019 Jun 7.

Abstract
摘要

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本文引用的文献

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Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C.
Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12964-12973. doi: 10.1073/pnas.1903781116. Epub 2019 May 28.
2
KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.
Sci Immunol. 2017 Sep 15;2(15). doi: 10.1126/sciimmunol.aal5296.
3
Resurrecting KIR2DP1: A Key Intermediate in the Evolution of Human Inhibitory NK Cell Receptors That Recognize HLA-C.
J Immunol. 2017 Mar 1;198(5):1961-1973. doi: 10.4049/jimmunol.1601835. Epub 2017 Jan 25.
4
Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy.
J Immunol. 2016 Dec 1;197(11):4292-4300. doi: 10.4049/jimmunol.1601279. Epub 2016 Nov 4.
5
KIR2DS4 promotes HIV-1 pathogenesis: new evidence from analyses of immunogenetic data and natural killer cell function.
PLoS One. 2014 Jun 5;9(6):e99353. doi: 10.1371/journal.pone.0099353. eCollection 2014.
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Controlling natural killer cell responses: integration of signals for activation and inhibition.
Annu Rev Immunol. 2013;31:227-58. doi: 10.1146/annurev-immunol-020711-075005.
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Human NK cell education by inhibitory receptors for MHC class I.
Immunity. 2006 Aug;25(2):331-42. doi: 10.1016/j.immuni.2006.06.013. Epub 2006 Aug 10.

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