有丝分裂中的蛋白质相分离。
Protein phase separation in mitosis.
机构信息
Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, United States.
Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, United States.
出版信息
Curr Opin Cell Biol. 2019 Oct;60:92-98. doi: 10.1016/j.ceb.2019.04.011. Epub 2019 Jun 5.
Abstract
Through phase separation, some proteins form liquid-like condensates or droplets which can flow, fuse, and even deform when pressure is applied. In some cases, the condensates 'mature' to form gel or solid-like structure. Recent studies suggest that the liquid-like condensates form the structural basis for several membrane-less subcellular organelles such as stress granules and other subcellular structures. Here, we review and discuss studies that implicate protein phase separation in the function of the spindle apparatus and centrosomes.
摘要
通过相分离，一些蛋白质形成类似液体的凝聚物或液滴，当受到压力时可以流动、融合甚至变形。在某些情况下，凝聚物“成熟”形成凝胶或类似固体的结构。最近的研究表明，类似液体的凝聚物为几种无膜亚细胞细胞器（如应激颗粒和其他亚细胞结构）的结构基础。在这里，我们回顾和讨论了表明蛋白质相分离在纺锤体装置和中心体功能中的作用的研究。
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