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急性食管坏死:黑暗中的视角

Acute Esophageal Necrosis: A View in the Dark.

作者信息

Khan Hafiz, Ahmed Moiz, Daoud Magda, Philipose Jobin, Ahmed Saba, Deeb Liliane

机构信息

Department of Gastroenterology, Staten Island University Hospital, Northwell Health, Staten Island, New York, USA.

Department of Gastroenterology, Mount Sinai School of Medicine, Elmhurst Hospital Center, Elmhurst, New York, USA.

出版信息

Case Rep Gastroenterol. 2019 Jan 16;13(1):25-31. doi: 10.1159/000496385. eCollection 2019 Jan-Apr.

Abstract

Acute esophageal necrosis (AEN), also known as Gurvits syndrome, black esophagus, or acute necrotizing esophagitis, is a rare clinical entity and an unusual reason for upper gastrointestinal bleeding. It is typically described in critically ill patients with multiple medical conditions, arising from a combination of ischemic insult to the esophageal mucosa due to low-flow vascular states, corrosive injury caused by reflux of acid and pepsin, and decreased function of the mucosal barrier systems and reparative mechanisms as occurs in malnourished and debilitated physical states. Patients with AEN tend to be older men, as medical comorbidities including vascular disease, diabetes, hypertension, renal insufficiency, cardiac disease, pulmonary disease, stroke, and cirrhosis may be more common. Typically, patients present with upper gastrointestinal bleeding, and hematemesis or melena is seen in up to 90% of cases. Herein we present 3 cases of AEN in critically ill patients. We also provide a review of the literature to highlight what is currently known about this relatively uncommon esophageal disease.

摘要

急性食管坏死(AEN),也称为古尔维茨综合征、黑色食管或急性坏死性食管炎,是一种罕见的临床病症,也是上消化道出血的不常见原因。它通常在患有多种疾病的重症患者中出现,是由低血流血管状态导致的食管黏膜缺血性损伤、胃酸和胃蛋白酶反流引起的腐蚀性损伤,以及营养不良和身体虚弱状态下黏膜屏障系统和修复机制功能下降共同作用所致。AEN患者多为老年男性,因为包括血管疾病、糖尿病、高血压、肾功能不全、心脏病、肺病、中风和肝硬化等在内的内科合并症可能更为常见。通常,患者会出现上消化道出血,高达90%的病例可见呕血或黑便。在此我们介绍3例重症患者的AEN病例。我们还对文献进行了综述,以突出目前对这种相对不常见的食管疾病的了解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44dd/6547274/5dc47522001f/crg-0013-0025-g01.jpg

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