中国交通警察职业暴露与高尿酸血症关联的队列研究。
Association between ambient air pollution and hyperuricemia in traffic police officers in China: a cohort study.
机构信息
Key Laboratories in Guangzhou, Guangzhou Medical University Institute of Occupational and Environmental Health, Guangzhou Occupational Disease Prevention and Treatment Hospital , Guangzhou, China.
Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University , Guangzhou, China.
出版信息
Int J Environ Health Res. 2021 Jan;31(1):54-62. doi: 10.1080/09603123.2019.1628926. Epub 2019 Jun 11.
To evaluate the association between ambient air pollution and hyperuricemia, we prospectively followed 1748 traffic police officers without hyperuricemia at baseline (2009-2014) from 11 districts in Guangzhou, China. We calculated six-year average PM, SO and NO concentrations using data collected from air monitoring stations. The hazard ratios for hyperuricemia per 10 µg/m increase in air pollutants were 1.46 (95% CI: 1.28-1.68) for PM, 1.23 (95% CI: 1.00-1.51) for SO, and 1.43 (95% CI: 1.26-1.61) for NO. We also identified changes in the ratio of serum uric acid to serum creatinine concentrations (ua/cre) per 10 µg/m increase in air pollutants as 11.54% (95% CI: 8.14%-14.93%) higher for PM, 5.09% (95% CI: 2.76%-7.42%) higher for SO, and 5.13% (95% CI: 2.35%-7.92%) higher for NO, respectively. Long-term exposure to ambient air pollution was associated with a higher incidence of hyperuricemia and an increase in ua/cre among traffic police officers.
为了评估环境空气污染与高尿酸血症之间的关联，我们前瞻性地随访了来自中国广州 11 个区的 1748 名基线时无高尿酸血症的交通警察（2009-2014 年）。我们使用空气监测站收集的数据计算了六年的平均 PM、SO 和 NO 浓度。污染物每增加 10μg/m³，高尿酸血症的危害比为 1.46（95%CI：1.28-1.68），PM 为 1.23（95%CI：1.00-1.51），SO 为 1.43（95%CI：1.26-1.61）。我们还发现，血清尿酸与血清肌酐浓度的比值（ua/cre）随污染物每增加 10μg/m³而分别升高 11.54%（95%CI：8.14%-14.93%）、5.09%（95%CI：2.76%-7.42%）和 5.13%（95%CI：2.35%-7.92%）。长期暴露于环境空气污染与交通警察高尿酸血症的发病率增加和 ua/cre 升高有关。
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