通过核糖体分析和术后氮利用评估，鸟氨酸-α-酮戊二酸可改善骨骼肌蛋白质合成。
Ornithine-alpha-ketoglutarate improves skeletal muscle protein synthesis as assessed by ribosome analysis and nitrogen use after surgery.
作者信息
Wernerman J, Hammarqvist F, von der Decken A, Vinnars E
机构信息
Department of Anesthesiology and Intensive Care, Huddinge University Hospital, Stockholm, Sweden.
出版信息
Ann Surg. 1987 Nov;206(5):674-8. doi: 10.1097/00000658-198711000-00020.
Total parenteral nutrition (TPN) was given for 3 days after elective abdominal surgery. The control group (N = 9) received TPN only and one group of patients (N = 6) received TPN supplemented with ornithine-alpha-ketoglutarate (0.35 g/kg bw/day). Protein synthesis in skeletal muscle was assessed from the total ribosome concentration and the percentage of polyribosomes. In the control group the total concentration of ribosomes decreased after surgery by 23% (p less than 0.05) and the percentage of polyribosomes decreased by 21% (p less than 0.01), whereas in the ornithine-alpha-ketoglutarate group both variables remained unaffected. The cumulative urinary urea excretion was significantly larger in the control group than in the ornithine-alpha-ketoglutarate group (p less than 0.05). The calculated nitrogen balance was negative in the control group on each day of the study (p less than 0.05), but that of the ornithine-alpha-ketoglutarate group was not statistically different from zero. The results show that postoperative maintenance of muscle protein synthesis and a more effective nitrogen use was achieved by supplementing TPN with ornithine-alpha-ketoglutarate, 0.35 g/kg bw/day.
择期腹部手术后给予全胃肠外营养（TPN）3天。对照组（n = 9）仅接受TPN，一组患者（n = 6）接受补充鸟氨酸α-酮戊二酸（0.35 g/kg体重/天）的TPN。根据总核糖体浓度和多核糖体百分比评估骨骼肌中的蛋白质合成。对照组术后核糖体总浓度下降23%（p < 0.05），多核糖体百分比下降21%（p < 0.01），而鸟氨酸α-酮戊二酸组这两个变量均未受影响。对照组累积尿尿素排泄量显著高于鸟氨酸α-酮戊二酸组（p < 0.05）。研究期间对照组每天计算的氮平衡均为负值（p < 0.05），而鸟氨酸α-酮戊二酸组的氮平衡与零无统计学差异。结果表明，每天补充0.35 g/kg体重的鸟氨酸α-酮戊二酸可维持术后肌肉蛋白质合成并更有效地利用氮。
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