使用胶原蛋白交联剂增强对腐蚀牙本质的粘结：2 年水储存。
Improving bonding to eroded dentin by using collagen cross-linking agents: 2 years of water storage.
机构信息
Department of Postgraduate Program in Dentistry, CEUMA University, São Luis, Maranhão, Brazil.
Department of Restorative Dentistry, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil.
出版信息
Clin Oral Investig. 2020 Feb;24(2):809-822. doi: 10.1007/s00784-019-02918-9. Epub 2019 Jun 12.
OBJECTIVES
The aim of this study was to investigate the effects of collagen cross-linking agents on nanomechanical and bonding properties of eroded dentin (ED), 24 h and 2 years after water storage.
MATERIALS AND METHODS
Human molar dentin surfaces, eroded by soft drinks or citric acid, were acid-etched and treated with primers containing proanthocyanidin (PA) and riboflavin (RI) or were untreated (control) and tested after 24 h and 2 years. After acid etching and adhesive application (Prime&Bond Elect (PBE); Scotchbond Universal (SBU); Tetric n-bond Universal (TEU)), specimens were sectioned into beams and tested for microtensile bond strength (μTBS) and silver nitrate deposition (NL) after 24 h and 2 years. The beams were used to evaluate the 24-h in situ conversion of degree (DC). Nanohardness (NH) and Young's modulus (YM) were evaluated via resin-bonded dentin slices after 24 h and 2 years. A three-way ANOVA and Tukey's test were used for statistical analysis (5%).
RESULTS
For both storage times, ED with citric acid resulted in lower μTBS, NH, and YM and higher NL for each adhesive system than soft drink ED (p < 0.05). After 2 years of water storage, cross-linking primers maintained the μTBS, NH, and YM (p < 0.05) when compared with the control group. Althougth, the NL values decreased for all groups after 2 years of water storage, PA and RI treatments showed NI values lower than control group (p < 0.001). No significant differences were observed between PA and RI treatments (p > 0.05). Cross-linking primers maintain or improve DC (p < 0.03). In general, TEU and SBU yielded higher μTBS, DC, NH, and YM and lower NL than PBE.
CONCLUSION
Cross-linking agents improved the results and maintained the resin-ED interface bonding and nanomechanical properties, without jeopardizing adhesive polymerization.
CLINICAL RELEVANCE
Cross-linking agents are a viable alternative for improving and maintaining resin-ED interface bonding and nanomechanical properties.
目的
本研究旨在探究胶原交联剂对经软饮料或柠檬酸侵蚀后的牙本质（ED）纳米力学和粘结性能的影响，以及在水储存 24 小时和 2 年后的影响。
材料和方法
用软饮料或柠檬酸侵蚀人磨牙牙本质表面，经酸蚀处理后，用含原花青素（PA）和核黄素（RI）的底漆处理（PA 和 RI 处理）或不处理（对照组），然后分别在 24 小时和 2 年后进行测试。在酸蚀和应用粘结剂（Prime&Bond Elect [PBE]；Scotchbond Universal [SBU]；Tetric n-bond Universal [TEU]）后，将标本制成梁试件，在 24 小时和 2 年后测试微拉伸粘结强度（μTBS）和硝酸银沉积（NL）。梁试件用于评估 24 小时原位转化率（DC）。通过树脂粘结牙本质切片评估纳米硬度（NH）和杨氏模量（YM），分别在 24 小时和 2 年后进行。采用三因素方差分析和 Tukey 检验进行统计学分析（5%）。
结果
对于两种储存时间，与软饮料 ED 相比，柠檬酸 ED 导致每个粘结系统的 μTBS、NH 和 YM 降低，NL 升高（p<0.05）。在水储存 2 年后，交联底漆与对照组相比，保持了 μTBS、NH 和 YM（p<0.05）。尽管所有组的 NL 值在 2 年后的水储存后均降低，但 PA 和 RI 处理的 NL 值均低于对照组（p<0.001）。PA 和 RI 处理之间未见显著差异（p>0.05）。交联底漆维持或提高 DC（p<0.03）。一般来说，TEU 和 SBU 产生的 μTBS、DC、NH 和 YM 更高，NL 更低，优于 PBE。
结论
交联剂可改善树脂-ED 界面粘结和纳米力学性能，且不会影响粘结剂聚合。
临床相关性
交联剂是改善和维持树脂-ED 界面粘结和纳米力学性能的一种可行选择。
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