感染领域的最新进展：聚焦疫苗研发。
Recent advances in infection: focus on vaccine development.
作者信息
Ansari Shamshul, Jha Rajesh Kumar, Mishra Shyam Kumar, Tiwari Birendra Raj, Asaad Ahmed Morad
机构信息
Department of Microbiology, Chitwan Medical College and Teaching Hospital, Bharatpur, Chitwan, Nepal.
Department of Systems and Diseases (Pharmacology), Saba University School of Medicine, Saba, Dutch Caribbean.
出版信息
Infect Drug Resist. 2019 May 13;12:1243-1255. doi: 10.2147/IDR.S175014. eCollection 2019.
Abstract
normally colonizes the nasal cavity and pharynx. After breaching the normal habitat, the organism is able to cause a number of infections at any site of the body. The development of antibiotic resistance has created a global challenge for treating infections. Therefore, protection by vaccines may provide valuable measures. Currently, several vaccine candidates have been prepared which are either in preclinical phase or in early clinical phase, whereas several candidates have failed to show a protective efficacy in human subjects. Approaches have also been made in the development of monoclonal or polyclonal antibodies for passive immunization to protect from infections. Therefore, in this review we have summarized the findings of recently published scientific literature to make a concise report.
摘要
通常定殖于鼻腔和咽部。突破正常栖息地后，该生物体能够在身体的任何部位引发多种感染。抗生素耐药性的发展给感染治疗带来了全球性挑战。因此，疫苗保护可能提供有价值的措施。目前，已经制备了几种候选疫苗，它们要么处于临床前阶段，要么处于临床早期阶段，而有几种候选疫苗在人体试验中未能显示出保护效果。在开发用于被动免疫以预防感染的单克隆或多克隆抗体方面也已取得进展。因此，在本综述中，我们总结了最近发表的科学文献的研究结果，以形成一份简要报告。
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