疾病的表观遗传因素
Epigenetic Factors of Disease.
作者信息
Alshiraihi Ilham, Brown Mark A
机构信息
Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, USA.
Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
出版信息
Diseases. 2019 Jun 14;7(2):42. doi: 10.3390/diseases7020042.
The development of tissues involves the direction of specific programs for gene expression among distinct cell types. These programs are often established in a heritable state by virtue of epigenetic mechanisms and corresponding pathways of cellular memory. Thus, the broad synchronization in patterns of gene expression ultimately dictates cellular consequences. Aberrations in these epigenetic mechanisms are known to be associated with a range of diseases. Herein, we highlight epigenetic factors that, when aberrantly expressed, lead to a broad range of diseases. Further, we call upon the community of biomedical researchers to share their findings related to the epigenetic factors of disease.
组织的发育涉及不同细胞类型中特定基因表达程序的导向。这些程序通常通过表观遗传机制和相应的细胞记忆途径以可遗传的状态建立。因此，基因表达模式的广泛同步最终决定了细胞的结果。已知这些表观遗传机制的异常与一系列疾病有关。在此，我们重点介绍那些异常表达时会导致多种疾病的表观遗传因素。此外，我们呼吁生物医学研究人员群体分享他们与疾病表观遗传因素相关的研究发现。
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