止吐药物对大鼠胚胎心脏活动的影响。
The effect of anti-emetic drugs on rat embryonic heart activity.
机构信息
Discipline of Anatomy and Histology, Sydney School of Medical Science, The University of Sydney, Sydney, NSW 2006, Australia.
Discipline of Anatomy and Histology, Sydney School of Medical Science, The University of Sydney, Sydney, NSW 2006, Australia.
出版信息
Reprod Toxicol. 2019 Aug;87:140-145. doi: 10.1016/j.reprotox.2019.06.002. Epub 2019 Jun 11.
Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine) used to treat NVP have the unwanted side effect of hERG blockade. The hERG potassium channel is essential for normal heart rhythm in both the adult human and the human and rat embryo. Animal studies show hERG blockade in the embryo causes bradycardia and arrhythmia leading to cardiovascular malformations and other birth defects. Whole rat embryo in vitro culture was used to determine the effect of the above listed AEM and meclizine on the heart rate of Gestational day 13 rat embryos. These embryos are similar in size and heart development to 5-6-week human embryo. The results showed that all of the AEMs caused a concentration-dependent bradycardia. Droperidol had the lowest margin of safety.
妊娠恶心和呕吐（NVP）是全球范围内最常见的妊娠医学主诉，影响高达 70%的孕妇。一些用于治疗 NVP 的止吐药物（AEM）（氟哌利多、多潘立酮、格拉司琼、甲氧氯普胺和三氟拉嗪）具有 hERG 阻断的不良副作用。hERG 钾通道对于成人和人类及大鼠胚胎的正常心律至关重要。动物研究表明，胚胎中的 hERG 阻断会导致心动过缓和心律失常，从而导致心血管畸形和其他出生缺陷。使用全大鼠胚胎体外培养来确定上述列出的 AEM 和倍他司汀对妊娠第 13 天大鼠胚胎心率的影响。这些胚胎在大小和心脏发育方面与 5-6 周的人类胚胎相似。结果表明，所有 AEM 均导致浓度依赖性心动过缓。氟哌利多的安全性最低。
Zotero 插件