冻存和再移植卵巢组织作为一种不孕治疗方法。
Cryostorage and retransplantation of ovarian tissue as an infertility treatment.
机构信息
Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium.
Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Avenue Mounier 52, bte. B1.52.02, 1200, Brussels, Belgium; Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University, Rua Cristóvão Colombo, 2265 Jardim Nazareth, 15054-000, São José do Rio Preto, São Paulo, Brazil.
出版信息
Best Pract Res Clin Endocrinol Metab. 2019 Feb;33(1):89-102. doi: 10.1016/j.beem.2018.09.002. Epub 2018 Sep 13.
While still considered an experimental procedure in most countries, ovarian tissue cryopreservation and transplantation has been increasingly applied worldwide to restore fertility in patients with malignant and non-malignant pathologies with risk of premature ovarian insufficiency. It has yielded more than 130 live births up to now and almost all transplanted patients recovered their ovarian function. This study summarizes ovarian tissue cryopreservation and transplantation indications, procedures, their efficacy and main results and proposes different strategies to improve this strategy. Although the main focus of this study is on ovarian tissue cryopreservation and transplantation as a strategy to restore fertility, we believe that it is also important to discuss other applications for this approach.
虽然在大多数国家仍被视为一种实验性程序，但卵巢组织冷冻保存和移植已在全球范围内越来越多地应用于有发生卵巢早衰风险的恶性和非恶性疾病患者，以恢复生育能力。迄今为止，已获得了超过 130 例活产，几乎所有接受移植的患者都恢复了卵巢功能。本研究总结了卵巢组织冷冻保存和移植的适应证、程序、疗效和主要结果，并提出了改善这一策略的不同策略。尽管本研究的主要重点是卵巢组织冷冻保存和移植作为恢复生育能力的策略，但我们认为讨论这种方法的其他应用也很重要。
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