Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea.
Department of Convergences, Kongju National University, Kongju 314-701, Korea.
Mar Drugs. 2019 Jun 12;17(6):350. doi: 10.3390/md17060350.
Marine organisms provide an abundant source of potential medicines. Many of the marine-derived biomaterials have been shown to act as different mechanisms in immune responses, and in each case they can significantly control the immune system to produce effective reactions. Marine-derived proteins, peptides, and protein hydrolysates exhibit various physiologic functions, such as antimicrobial, anticancer, antioxidant, antihypertensive, and anti-inflammatory activities. Recently, the immunomodulatory properties of several antimicrobial peptides have been demonstrated. Some of these peptides directly kill bacteria and exhibit a variety of immunomodulatory activities that improve the host innate immune response and effectively eliminate infection. The properties of immunomodulatory proteins and peptides correlate with their amino acid composition, sequence, and length. Proteins and peptides with immunomodulatory properties have been tested in vitro and in vivo, and some of them have undergone different clinical and preclinical trials. This review provides a comprehensive overview of marine immunomodulatory proteins, peptides, and protein hydrolysates as well as their production, mechanisms of action, and applications in human therapy.
海洋生物为潜在药物提供了丰富的来源。许多海洋衍生生物材料已被证明在免疫反应中具有不同的作用机制，在每种情况下，它们都可以显著控制免疫系统产生有效的反应。海洋衍生的蛋白质、肽和蛋白质水解物具有多种生理功能，如抗菌、抗癌、抗氧化、降压和抗炎活性。最近，一些抗菌肽的免疫调节特性已经得到证实。其中一些肽直接杀死细菌，并表现出多种免疫调节活性，可改善宿主固有免疫反应并有效消除感染。免疫调节蛋白和肽的特性与其氨基酸组成、序列和长度有关。具有免疫调节特性的蛋白质和肽已在体外和体内进行了测试，其中一些已进行了不同的临床前和临床试验。本综述全面概述了海洋免疫调节蛋白、肽和蛋白质水解物及其在人类治疗中的生产、作用机制和应用。
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