[Effect of prostaglandins on metastatic spread after surgical removal of tumors and pain stress in mice].

The effect of prostaglandins (PG) E2 and F2 alpha, indomethacin and arachidonic acid on stressful metastatic stimulation observed in case of combined stress influence has been studied in C57Bl mice with Lewis carcinoma. Under conditions of excessive stress load indomethacin, arachidonic acid and PGF2 alpha stimulated the development of metastases, while PGE2 caused an inhibiting effect. On the contrary, in animals which were not affected by stress indomethacin and PGF2 alpha revealed an antimetastatic effect.