三阴性乳腺癌中MET T1010I和MET rs40239单核苷酸多态性的评估：一项病例对照研究。

Evaluation of MET T1010I and MET rs40239 single-nucleotide polymorphisms in triple-negative breast cancer: a case-control study.

作者信息

Kalapanida Despoina, Zagouri Flora, Gazouli Maria, Tsiakou Andriani, Zografos Eleni, Dimitrakakis Constantine, Marinopoulos Spyridon, Giannos Aris, Sergentanis Theodoros N, Kastritis Efstathios, Terpos Evangelos, Dimopoulos Meletios-Athanassios

机构信息

Department of Clinical Therapeutic, Alexandra Hospital, Medical School, University of Athens, Athens, Greece.

Department of Basic Medical Sciences, Laboratory of Biology, University of Athens School of Medicine and Laboratory of Cell and Gene Therapy, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

出版信息

Onco Targets Ther. 2019 May 28;12:4195-4202. doi: 10.2147/OTT.S189329. eCollection 2019.

DOI:10.2147/OTT.S189329

PMID:31213837

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6549390/

Abstract

The purpose of this study is to evaluate the role of MET T1010I and MET rs40239 as potential risk factor and/or prognostic markers in patients with triple-negative breast cancer (TNBC). 114 samples of DNA from paraffin-embedded breast normal tissues of patients with TNBC and 124 samples of healthy controls were collected and analyzed for MET T1010I and MET rs40239 polymorphisms. MET T1010I CT genotype was associated with increased risk of TNBC in both univariate and multivariate analysis. The status of rs40239 was not associated with a higher risk for TNBC at either the univariate or the multivariate analysis. None of the examined polymorphisms was associated with overall survival at the univariate or multivariate Cox regression analysis (adjusted HR=1.35, 95% CI: 0.31-5.97 for MET T1010I CT/TT vs CC; adjusted HR=1.78, 95% CI: 0.73-4.35 for rs40239 AG/GG vs AA). Our case-control study suggests that MET T1010I seems to be a risk factor for TNBC in the Caucasian Greek population, in contrast with MET rs40239, where no correlation was found.

摘要

本研究的目的是评估MET T1010I和MET rs40239作为三阴性乳腺癌（TNBC）患者潜在风险因素和/或预后标志物的作用。收集了114例TNBC患者石蜡包埋乳腺正常组织的DNA样本以及124例健康对照样本，并对MET T1010I和MET rs40239多态性进行分析。在单因素和多因素分析中，MET T1010I CT基因型均与TNBC风险增加相关。在单因素或多因素分析中，rs40239的状态与TNBC的较高风险均无关联。在单因素或多因素Cox回归分析中，所检测的多态性均与总生存期无关（MET T1010I CT/TT与CC相比，校正风险比=1.35，95%置信区间：0.31-5.97；rs40239 AG/GG与AA相比，校正风险比=1.78，95%置信区间：0.73-4.35）。我们的病例对照研究表明，在希腊白种人群中，与未发现相关性的MET rs40239相反，MET T1010I似乎是TNBC的一个风险因素。