莱姆病螺旋体研究的最新发现与进展
Recent discoveries and advancements in research on the Lyme disease spirochete .
作者信息
Winslow Christa, Coburn Jenifer
机构信息
Department of Microbiology and Immunology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.
出版信息
F1000Res. 2019 May 31;8. doi: 10.12688/f1000research.18379.1. eCollection 2019.
Abstract
This review highlights some of the highest-profile developments and advancements in the research on , the Lyme disease spirochete, that have emerged in the last two years. Particular emphasis is placed on the controversy surrounding genus nomenclature, antigenic variation at the locus, genes involved in infectivity and virulence, membrane characteristics of , and developments in experimental approaches.
摘要
本综述重点介绍了过去两年中莱姆病螺旋体研究方面的一些最引人注目的进展。特别强调了围绕属名命名法的争议、 位点的抗原变异、与感染性和毒力相关的基因、 的膜特性以及实验方法的进展。
相似文献
1
Recent discoveries and advancements in research on the Lyme disease spirochete .
F1000Res. 2019 May 31;8. doi: 10.12688/f1000research.18379.1. eCollection 2019.
2
Transcriptional regulation of the Borrelia burgdorferi antigenically variable VlsE surface protein.
J Bacteriol. 2006 Jul;188(13):4879-89. doi: 10.1128/JB.00229-06.
3
Effects of vlsE complementation on the infectivity of Borrelia burgdorferi lacking the linear plasmid lp28-1.
Infect Immun. 2004 Nov;72(11):6577-85. doi: 10.1128/IAI.72.11.6577-6585.2004.
4
New Zealand White Rabbits Effectively Clear Borrelia burgdorferi B31 despite the Bacterium's Functional Antigenic Variation System.
Infect Immun. 2019 Jun 20;87(7). doi: 10.1128/IAI.00164-19. Print 2019 Jul.
5
Lack of detectable variation at Borrelia burgdorferi vlsE locus in ticks.
J Med Entomol. 2007 Jan;44(1):168-70. doi: 10.1603/0022-2585(2007)44[168:lodvab]2.0.co;2.
6
Characterization of the vls antigenic variation loci of the Lyme disease spirochaetes Borrelia garinii Ip90 and Borrelia afzelii ACAI.
Mol Microbiol. 2003 Mar;47(5):1407-17. doi: 10.1046/j.1365-2958.2003.03386.x.
7
vls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework Heterogeneity.
Microbiol Spectr. 2014 Dec;2(6). doi: 10.1128/microbiolspec.MDNA3-0038-2014.
8
Changing of the guard: How the Lyme disease spirochete subverts the host immune response.
J Biol Chem. 2020 Jan 10;295(2):301-313. doi: 10.1074/jbc.REV119.008583. Epub 2019 Nov 21.
9
Investigating the potential role of non-vls genes on linear plasmid 28-1 in virulence and persistence by Borrelia burgdorferi.
BMC Microbiol. 2016 Aug 8;16(1):180. doi: 10.1186/s12866-016-0806-4.
10
Identification of potential virulence determinants by Himar1 transposition of infectious Borrelia burgdorferi B31.
Infect Immun. 2006 Dec;74(12):6690-9. doi: 10.1128/IAI.00993-06. Epub 2006 Oct 2.
引用本文的文献
1
Characterization of the family-level pan-genome and development of an episomal typing protocol.
mBio. 2025 Jun 11;16(6):e0094325. doi: 10.1128/mbio.00943-25. Epub 2025 May 7.
2
Outer membrane vesicles in gram-negative bacteria and its correlation with pathogenesis.
Front Immunol. 2025 Apr 1;16:1541636. doi: 10.3389/fimmu.2025.1541636. eCollection 2025.
3
Characterization of the family-level Borreliaceae pan-genome and development of an episomal typing protocol.
Res Sq. 2024 Jun 11:rs.3.rs-4491589. doi: 10.21203/rs.3.rs-4491589/v1.
4
Borreliae Part 1: Borrelia Lyme Group and Echidna-Reptile Group.
Biology (Basel). 2021 Oct 12;10(10):1036. doi: 10.3390/biology10101036.
5
Monitoring of Hydrogen Emission from Bacteria in Food, Animals and in the Blood of Humans Suffering from Lyme Disease by A Specific Hydrogen Sensor.
Antibiotics (Basel). 2020 Jul 21;9(7):427. doi: 10.3390/antibiotics9070427.
本文引用的文献
1
Phyloproteomic and functional analyses do not support a split in the genus Borrelia (phylum Spirochaetes).
BMC Evol Biol. 2019 Feb 13;19(1):54. doi: 10.1186/s12862-019-1379-2.
2
The genus Borrelia reloaded.
PLoS One. 2018 Dec 26;13(12):e0208432. doi: 10.1371/journal.pone.0208432. eCollection 2018.
3
Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi.
Mol Microbiol. 2019 Mar;111(3):750-763. doi: 10.1111/mmi.14189. Epub 2019 Jan 31.
4
Fluorescent Proteins, Promoters, and Selectable Markers for Applications in the Lyme Disease Spirochete Borrelia burgdorferi.
Appl Environ Microbiol. 2018 Nov 30;84(24). doi: 10.1128/AEM.01824-18. Print 2018 Dec 15.
5
Public health and patient safety concerns merit retention of Lyme borreliosis-associated spirochetes within the genus Borrelia, and rejection of the genus novum Borreliella.
Ticks Tick Borne Dis. 2019 Jan;10(1):1-4. doi: 10.1016/j.ttbdis.2018.08.010. Epub 2018 Aug 20.
6
Microbiological features distinguishing Lyme disease and relapsing fever spirochetes.
Wien Klin Wochenschr. 2018 Aug;130(15-16):484-490. doi: 10.1007/s00508-018-1368-2. Epub 2018 Aug 3.
7
A Borrelia burgdorferi mini-vls system that undergoes antigenic switching in mice: investigation of the role of plasmid topology and the long inverted repeat.
Mol Microbiol. 2018 Sep;109(5):710-721. doi: 10.1111/mmi.14071. Epub 2018 Sep 9.
8
Borrelia burgdorferi surface-located Lmp1 protein processed into region-specific polypeptides that are critical for microbial persistence.
Cell Microbiol. 2018 Sep;20(9):e12855. doi: 10.1111/cmi.12855. Epub 2018 May 25.
9
Lipid rafts can form in the inner and outer membranes of Borrelia burgdorferi and have different properties and associated proteins.
Mol Microbiol. 2018 Apr;108(1):63-76. doi: 10.1111/mmi.13914. Epub 2018 Feb 15.
10
Northward range expansion of Ixodes scapularis evident over a short timescale in Ontario, Canada.
PLoS One. 2017 Dec 27;12(12):e0189393. doi: 10.1371/journal.pone.0189393. eCollection 2017.
Zotero 插件