重新审视疟原虫配子体生物学。
Revisiting gametocyte biology in malaria parasites.
机构信息
Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, 120 University Road, Glasgow G12 8TA, UK.
Core Facilities, Microscopy Area, Instituto Superiore di Sanita, Via Regina Elena 299, 00161 Rome, Italy.
出版信息
FEMS Microbiol Rev. 2019 Jul 1;43(4):401-414. doi: 10.1093/femsre/fuz010.
Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito vector. They are present at low levels in blood circulation and significant knowledge gaps exist in their biology. Recent reductions in the global malaria burden have brought the possibility of elimination and eradication, with renewed focus on malaria transmission biology as a basis for interventions. This review discusses recent insights into gametocyte biology in the major human malaria parasite, Plasmodium falciparum and related species.
配子体是唯一可传播给疟蚊媒介的疟原虫形式。它们在血液循环中的含量很低，其生物学特性仍存在大量知识空白。全球疟疾负担的近期减少使消除和根除疟疾成为可能，人们重新关注疟原虫传播生物学，以此作为干预的基础。本文讨论了近期对主要人类疟原虫（恶性疟原虫和相关物种）配子体生物学的新认识。
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